The roles of FLOT1 in human diseases (Review)

FLOT1, a scaffold protein of lipid rafts, is involved in several biological processes, including raft protein‑­dependent or clathrin‑independent endocytosis, and the formation hippocampal synapses, amongst others. Increasing evidence has shown that FLOT1 can function as both cancer promoter suppressor dependent on type cancer. affect occurrence development types by affecting epithelial‑mesenchymal transition, proliferation cells, relevant signaling pathways, regulated long intergenic non‑coding RNAs microRNAs. In nervous system, overexpression abnormally low expression may lead to neurological diseases, such Alzheimer's disease, Parkinson's major depressive disorder other diseases. Additionally, it also associated with dilated cardiomyopathy, pathogenic microbial infection, diabetes‑related gynecological present review, structure localization well physiological processes are reviewed, then upstream downstream regulation human particularly different diseases discussed, focus potentially targeting for clinical treatment